Description

Boc-(R)-α-(2-Furanylmethyl)-Proline is a high-purity, non-natural amino acid derivative featuring a Boc-protected proline core with a chiral furanylmethyl side chain. This compound matters as a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutics, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a constrained, non-natural proline analog into peptide chains.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various enzymes like kinases and proteases.
• Chemical Biology Research: Employed as a molecular probe or building block to study protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions.
• Academic & Institutional Research: Used in university and institutional labs for advanced organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	Boc-(R)-α-(2-Furanylmethyl)-Proline
CAS No.	959582-72-0
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	(R)-1-[(tert-Butoxycarbonyl)-2-(2-furanylmethyl)proline]; Boc-(R)-α-(2-Furylmethyl)proline; tert-Butyl (R)-2-[(furan-2-yl)methyl]pyrrolidine-1-carboxylate; (R)-N-Boc-2-(2-Furylmethyl)proline; 1-Boc-2-[(2-furyl)methyl]-(R)-proline; (R)-1-(tert-Butoxycarbonyl)-2-(2-furanylmethyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-(2-Furanylmethyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.