Description

n-(tert-Butoxy)Carbonyl (2R,3R)-3-Amino-3-(3-Fluoro-Phenyl)-2-Hydroxypropionic Acid is a high-purity, chiral amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a fluorinated aromatic side chain. This compound is a critical pharmaceutical intermediate used in the synthesis of complex active pharmaceutical ingredients (APIs), where its defined stereochemistry and fluorine atom are essential for biological activity and metabolic stability. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other targeted small molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in research and production of inhibitors for enzymes like renin, HIV protease, and thrombin.
• Peptidomimetics Synthesis: Incorporated into peptide analogs to enhance stability, bioavailability, and target specificity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in stereoselective chemical reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize drug candidate properties.
• Bioconjugation: Potential use in creating labeled compounds or antibody-drug conjugates (ADCs) due to its reactive functional groups.

Basic Information

Product Name	n-(tert-Butoxy)Carbonyl (2R,3R)-3-Amino-3-(3-Fluoro-Phenyl)-2-Hydroxypropionic Acid
CAS No.	959580-32-6
Molecular Formula	C₁₄H₁₈FNO₅
Molecular Weight	299.30 g/mol
Synonyms	Boc-(2R,3R)-3-Amino-3-(3-fluorophenyl)-2-hydroxypropionic Acid; (2R,3R)-3-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)-2-hydroxypropanoic Acid; (2R,3R)-N-Boc-3-Amino-3-(3-fluorophenyl)-2-hydroxypropionic Acid; (2R,3R)-3-(Boc-amino)-3-(3-fluorophenyl)-2-hydroxypropanoic Acid; (2R,3R)-3-(tert-Butoxycarbonylamino)-3-(3-fluorophenyl)-2-hydroxypropionic Acid; (2R,3R)-Boc-AHP(3-F)-OH; (2R,3R)-Boc-3-Amino-3-(3-fluoro-phenyl)-2-hydroxy-propionic Acid
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxy)Carbonyl (2R,3R)-3-Amino-3-(3-Fluoro-Phenyl)-2-Hydroxypropionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.