Description

(tert-Butoxy)Carbonyl (R)-α-(4-Thiazolylmethyl)-Pro is a high-purity, chiral building block featuring a protected amino acid scaffold and a thiazole heterocycle. This compound is critical for the synthesis of complex, biologically active molecules where stereochemical integrity and specific functional group compatibility are paramount. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and advanced material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and antiviral drug discovery programs.
• Peptidomimetic Synthesis: Used to incorporate non-natural amino acid residues into peptide chains to enhance stability, bioavailability, and target specificity.
• Agrochemical Research: Serves as a building block for developing new chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: The thiazole moiety and chiral center make it a valuable precursor for creating specialized ligands in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Item	Detail
Product Name	(tert-Butoxy)Carbonyl (R)-α-(4-Thiazolylmethyl)-Pro
CAS No.	959578-31-5
Molecular Formula	C14H22N2O4S
Molecular Weight	314.40 g/mol
Synonyms	Boc-(R)-α-(4-Thiazolylmethyl)-Proline; (R)-1-[(tert-Butoxy)carbonyl]-2-(thiazol-4-ylmethyl)pyrrolidine-2-carboxylic acid; (R)-Boc-4-Thiazolylmethyl-Pro-OH; (R)-N-Boc-2-(4-Thiazolylmethyl)proline; (R)-2-(1,3-Thiazol-4-ylmethyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid; (R)-Boc-Thz-Pro; Boc-(R)-Tzm-Pro
EINECS	Contact for details

Quality Control

Every batch of (tert-Butoxy)Carbonyl (R)-α-(4-Thiazolylmethyl)-Pro is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and residual solvent levels is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.