Description

Boc-(R)-(2-Nitrobenzyl)-Proline is a protected, non-proteinogenic amino acid derivative that serves as a crucial chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex peptide mimetics and pharmaceutical intermediates with high stereochemical fidelity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme modulators, and other bioactive peptide-based molecules.
• Peptidomimetic Research: Used to introduce constrained proline analogs and unnatural amino acids into peptide backbones to enhance stability and biological activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Chemical Biology Probes: Incorporated into activity-based probes and molecular tags for studying enzyme function and protein-protein interactions.
• Agrochemical Development: Serves as a building block for novel herbicides, fungicides, and plant growth regulators with specific chiral requirements.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and the exploration of new chemical space in medicinal chemistry.

Basic Information

Product Name	Boc-(R)-(2-Nitrobenzyl)-Proline
CAS No.	959578-20-2
Molecular Formula	C17H22N2O6
Molecular Weight	350.37 g/mol
Synonyms	(R)-1-[(2-Nitrobenzyl)]-2-[(tert-Butoxycarbonyl)]pyrrolidine-2-carboxylic Acid; (R)-1-(2-Nitrobenzyl)-2-((tert-butoxycarbonyl)amino)pyrrolidine-2-carboxylic Acid; Boc-(R)-N-(2-Nitrobenzyl)proline; tert-Butyl (R)-1-(2-nitrobenzyl)-2-carboxypyrrolidine-1-carboxylate; (R)-N-Boc-N-(2-nitrobenzyl)proline; (R)-N-(tert-Butoxycarbonyl)-N-(2-nitrobenzyl)proline; (2R)-1-[(2-Nitrophenyl)methyl]-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-(R)-(2-Nitrobenzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.