Description

Boc-(R)-α-(3-Fluorobenzyl)-Proline is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a fluorinated benzyl side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex, biologically active molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel peptide-based therapeutics and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for metabolic and central nervous system (CNS) disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a fluorinated, non-natural proline analog into peptide chains, enhancing metabolic stability and binding affinity.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various enzymes like dipeptidyl peptidase-4 (DPP-4) and other proteases.
• Chemical Biology & Probe Design: Employed to create labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry & Scale-Up: Used in the development of scalable synthetic routes for active pharmaceutical ingredients (APIs) under current Good Manufacturing Practice (cGMP) standards.
• Academic Research: A valuable reagent for universities and research institutes exploring novel peptide architectures and fluorine chemistry in medicinal applications.

Basic Information

Product Name	Boc-(R)-α-(3-Fluorobenzyl)-Proline
CAS No.	959578-16-6
Molecular Formula	C18H24FNO4
Molecular Weight	337.39 g/mol
Synonyms	(R)-1-[(tert-Butoxy)carbonyl]-3-[(3-fluorophenyl)methyl]-2-pyrrolidinecarboxylic acid; (R)-1-Boc-3-(3-fluorobenzyl)proline; Boc-(R)-3-(3-Fluorobenzyl)proline; (R)-N-Boc-3-(3-Fluorobenzyl)proline; (R)-1-(tert-Butoxycarbonyl)-3-(3-fluorobenzyl)proline; (R)-3-(3-Fluorobenzyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]-2-pyrrolidinecarboxylic acid; (R)-N-tert-Butoxycarbonyl-3-(3-fluorobenzyl)proline
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-(3-Fluorobenzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for identity, purity (by HPLC), chiral purity, and residual solvents. We support development from research to commercial scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.