Description

Boc-(R)-α-(2-Fluorobenzyl)-Proline is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a chiral 2-fluorobenzyl side chain. This compound is a critical chiral building block in modern pharmaceutical research, particularly for the synthesis of peptide-based drugs and protease inhibitors. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology industries for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), especially for protease inhibitors and other peptide mimetics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a fluorinated, non-natural amino acid residue, modulating the peptide's biological activity, stability, and pharmacokinetic properties.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies, enabling the exploration of new chemical space in drug discovery programs.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides or activity-based probes for studying enzyme function and protein-protein interactions.
• Process Chemistry & Scale-up: Suitable for use in the development and optimization of scalable synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Boc-(R)-α-(2-Fluorobenzyl)-Proline
CAS No.	959576-66-0
Molecular Formula	C₁₈H₂₄FNO₄
Molecular Weight	337.39 g/mol
Synonyms	(R)-1-[(tert-Butoxy)carbonyl]-2-(2-fluorobenzyl)pyrrolidine-2-carboxylic acid; (R)-1-Boc-2-(2-fluorobenzyl)proline; Boc-(R)-2-(2-Fluorobenzyl)proline; (R)-N-Boc-2-(2-Fluorobenzyl)proline; (R)-2-(2-Fluorobenzyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; (R)-1-(tert-Butoxycarbonyl)-2-(2-fluorobenzyl)proline; 959576-66-0; BOC-(R)-A-(2-FLUOROBENZYL)-PROLINE
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-(2-Fluorobenzyl)-Proline is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, meeting the stringent requirements of pharmaceutical R&D. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We adhere to relevant quality management standards to ensure reliable supply and batch-to-batch consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.