Description

Boc-(R)-α-(4-Iodo-Benzyl)-Proline is a high-purity, non-natural amino acid derivative featuring a chiral proline core protected by a tert-butyloxycarbonyl (Boc) group and substituted with a 4-iodobenzyl moiety. This compound matters as a critical, structurally-defined building block for the synthesis of complex peptides and peptidomimetics, enabling advanced pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for creating novel drug candidates and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides, protease inhibitors, and receptor ligands.
• Peptidomimetic Design: Used to introduce conformational constraints and specific pharmacophores into peptide backbones to enhance stability, potency, and selectivity.
• Chemical Biology Probes: Serves as a building block for synthesizing labeled or tagged peptides used in target identification and mechanism-of-action studies.
• Agrochemical Research: Employed in the discovery of new peptide-based herbicides, fungicides, or plant growth regulators.
• Academic Research: Utilized in university and institutional labs for studying peptide structure-activity relationships and developing new synthetic methodologies.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides and complex organic molecules for clients.

Basic Information

Product Name	Boc-(R)-α-(4-Iodo-Benzyl)-Proline
CAS No.	959576-49-9
Molecular Formula	C₁₇H₂₂INO₄
Molecular Weight	431.27 g/mol
Synonyms	(R)-1-[(tert-Butoxycarbonyl)-4-(4-iodobenzyl)proline]; Boc-(R)-4-(4-Iodobenzyl)proline; tert-Butyl (R)-4-(4-iodobenzyl)proline-1-carboxylate; (R)-N-Boc-4-(4-Iodobenzyl)proline; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[(4-iodophenyl)methyl]-(R)-proline; Boc-4-(4-Iodobenzyl)-D-proline; Boc-(R)-α-(4-Iodobenzyl)proline; 959576-49-9
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-(4-Iodo-Benzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (HPLC), and specific rotation are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.