Description

(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-Iodobenzyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a protected pyrrolidine scaffold with an iodobenzyl side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, valued for its structural complexity and versatility in synthesis. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents, particularly in the areas of protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially for targeting proteases and other enzymes.
• Peptidomimetic Synthesis: Used to construct complex peptidomimetic structures where the constrained pyrrolidine ring and aromatic iodine moiety are essential for biological activity and binding affinity.
• Chemical Biology Probe Development: Acts as a versatile scaffold for creating chemical probes to study enzyme function and protein-protein interactions, leveraging the iodine atom for potential further functionalization.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Library Synthesis for Drug Discovery: A valuable building block for generating diverse compound libraries in high-throughput screening campaigns to identify new lead structures.

Basic Information

Product Name	(2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-Iodobenzyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	959573-98-9
Molecular Formula	C17H22INO4
Molecular Weight	431.27 g/mol
Synonyms	Boc-4-(4-Iodobenzyl)-D-proline; (2S,4R)-1-Boc-4-(4-Iodobenzyl)pyrrolidine-2-carboxylic acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[(4-iodophenyl)methyl]-2-pyrrolidinecarboxylic acid, (2S,4R)-; 4-(4-Iodobenzyl)-D-proline tert-butyl ester; (2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-iodobenzyl)-2-pyrrolidinecarboxylic acid; (2S,4R)-4-(4-Iodobenzyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-(tert-Butoxycarbonyl)-4-(4-Iodobenzyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.