Description

(2S,4S)-4-Benzhydryl-1-(tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, stereochemically defined chiral building block of significant importance in modern pharmaceutical synthesis. This compound is valued for its rigid, functionalized pyrrolidine core, which serves as a key scaffold for constructing complex molecules with defined three-dimensional architecture. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring precise stereochemical control, such as protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, especially for targeting proteases and other enzymes.
• Peptidomimetic Chemistry: Used to construct constrained peptide analogs and peptidomimetics to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Process Development: Used in the scale-up and optimization of synthetic routes for potential commercial Active Pharmaceutical Ingredients.
• Chemical Biology Probes: Incorporated into molecular probes to study biological pathways and protein-ligand interactions.

Basic Information

Product Name	(2S,4S)-4-Benzhydryl-1-(tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	959573-18-3
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	1-Boc-4-benzhydryl-(2S,4S)-proline; (2S,4S)-1-(tert-Butoxycarbonyl)-4-(diphenylmethyl)-2-pyrrolidinecarboxylic Acid; 4-(Diphenylmethyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]-L-proline; (2S,4S)-4-(Diphenylmethyl)-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic Acid; Boc-(2S,4S)-4-Benzhydryl-proline; (2S,4S)-4-Benzhydryl-1-Boc-pyrrolidine-2-carboxylic Acid; (2S,4S)-1-Boc-4-(diphenylmethyl)proline
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Benzhydryl-1-(tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; desiccants are recommended for long-term storage. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.