Description

(S)-n-Methyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-3-Yl)Propan-1-Amine Hydrochloride is a high-purity chiral amine hydrochloride salt, a key intermediate in advanced pharmaceutical synthesis. Its value lies in its defined stereochemistry and functional groups, which are critical for constructing complex molecules with specific biological activity. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, particularly those focused on central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeted drugs.
• Chiral Synthesis: Used in asymmetric synthesis to introduce a specific stereocenter, crucial for developing enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable manufacturing of complex organic molecules.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents requiring specific chiral architectures.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in regulatory submissions.

Basic Information

Item	Detail
Product Name	(S)-n-Methyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-3-Yl)Propan-1-Amine Hydrochloride
CAS No.	959392-22-4
Molecular Formula	C18H20ClNOS
Molecular Weight	333.87 g/mol
Synonyms	(S)-N-Methyl-3-(1-naphthyloxy)-3-(3-thienyl)propylamine hydrochloride; (S)-1-(Methylamino)-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propane hydrochloride; (S)-N-Methyl-3-(1-naphthoxy)-3-(3-thienyl)propylamine HCl; (S)-3-(1-Naphthyloxy)-3-(3-thienyl)-N-methylpropylamine hydrochloride; Duloxetine Impurity; Duloxetine Related Compound; (S)-Duloxetine Intermediate
EINECS	Contact for details

Quality Control

Our (S)-n-Methyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-3-Yl)Propan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.