Description

4-Pentyn-2-ol, 5-[(1,1-dimethylethyl)dimethylsilyl]- is a specialized organosilicon-protected alkynol building block, identified by CAS number 959313-55-4. This compound is valued for its dual functionality, offering a protected hydroxyl group and a terminal alkyne, which are crucial for controlled synthetic transformations in advanced organic chemistry. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical sectors for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly in Sonogashira coupling and click chemistry reactions.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where specific alkynyl motifs are required for biological activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with tailored properties.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in bio-conjugation and labeling strategies due to its reactive alkyne handle for Huisgen cycloaddition.
• Academic & Industrial R&D: A versatile building block for methodological development and exploratory synthesis in organic chemistry laboratories.

Basic Information

Product Name	4-Pentyn-2-ol, 5-[(1,1-dimethylethyl)dimethylsilyl]-
CAS No.	959313-55-4
Molecular Formula	C11H22OSi
Molecular Weight	198.38 g/mol
Synonyms	5-(tert-Butyldimethylsilyl)-4-pentyn-2-ol; 4-Pentyn-2-ol, 5-[(1,1-dimethylethyl)dimethylsilyl]-; 5-(Tert-butyldimethylsilyl)pent-4-yn-2-ol; TBDMS-protected 4-pentyn-2-ol; tert-Butyldimethyl(4-hydroxybut-1-yn-1-yl)silane; 959313-55-4; 5-(tert-Butyldimethylsilyl)-4-pentyn-2-ol
EINECS	Contact for details

Quality Control

Our production of 4-Pentyn-2-ol, 5-[(1,1-dimethylethyl)dimethylsilyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by comprehensive analytical techniques including NMR, GC, and HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to strong acids and strong bases/fluorides; keep away from incompatible materials. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.