Description

tert-Butyldimethylsilane is a versatile organosilicon compound widely used as a key reagent and protecting group in advanced organic synthesis. Its primary value lies in its ability to introduce the robust tert-butyldimethylsilyl (TBDMS) group, which is crucial for protecting sensitive functional groups like alcohols and amines during complex multi-step reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for introducing the TBDMS protecting group in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of advanced pesticides, herbicides, and fungicides where selective protection of hydroxyl groups is required.
• Peptide and Oligonucleotide Chemistry: Employed for the protection of nucleosides, nucleotides, and amino acids during solid-phase and solution-phase synthesis.
• Natural Product and Fine Chemical Synthesis: Facilitates the synthesis of complex natural products, flavors, fragrances, and other high-value fine chemicals.
• Material Science Research: Serves as a precursor or silylating agent in the surface modification of materials and the development of silicon-based polymers.
• Process Chemistry & Scale-up: Utilized in pilot plants and commercial-scale manufacturing for processes requiring reliable and efficient silylation.

Basic Information

Product Name	tert-Butyldimethylsilane
CAS No.	29681-57-0
Molecular Formula	C6H16Si
Molecular Weight	116.28 g/mol
Synonyms	TBDMS-H; tert-Butyldimethylsilicon hydride; Dimethyl(tert-butyl)silane; (1,1-Dimethylethyl)dimethylsilane; t-Butyldimethylsilane; tert-Butyldimethylsilyl hydride; TBDMS Hydride; Dimethyl-tert-butylsilane
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is rigorously tested via GC, NMR, and Karl Fischer titration to confirm identity, purity, and moisture content. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support cGMP compliance for pharmaceutical applications, and our quality systems are designed to meet the stringent requirements of global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and highly volatile. For long-term storage, consider keeping the container under an inert atmosphere (nitrogen or argon) in a dedicated flammables cabinet, away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Report on COA
Density (20°C)	~0.72 g/mL
Refractive Index (n20D)	~1.405

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.