Description

Trimethylsilylacetylene is a versatile organosilicon building block, widely recognized for its role as a protected acetylene equivalent in organic synthesis. This compound is essential for introducing the ethynyl group into complex molecules under mild conditions, enabling the construction of advanced intermediates. It is a critical reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, facilitating the synthesis of active ingredients, polymers, and specialty chemicals.

Application

• Pharmaceutical Intermediates: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators requiring acetylene-derived structures.
• Material Science & Polymers: Serves as a monomer or functionalizing agent for creating silicon-containing polymers, dendrimers, and advanced organic electronic materials.
• Organic Synthesis & Research: A fundamental reagent for constructing carbon-carbon bonds, used in laboratories for synthesizing natural products, ligands, and complex organic frameworks.
• Liquid Crystal & OLED Materials: Employed in the synthesis of precursors for liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Protecting Group Strategy: The trimethylsilyl group acts as a protective moiety for terminal alkynes, which can be selectively removed (desilylated) when needed.

Basic Information

Product Name	Trimethylsilylacetylene
CAS No.	1066-54-2
Molecular Formula	C5H10Si
Molecular Weight	98.22 g/mol
Synonyms	Ethynyltrimethylsilane; TMS-acetylene; Trimethylsilylethyne; (Trimethylsilyl)acetylene; TMSA; Silane, ethynyltrimethyl-; 1-Trimethylsilylacetylene
EINECS	213-964-7

Quality Control

Our Trimethylsilylacetylene is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC and NMR analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat, sparks, and open flame. Due to its highly volatile nature, keep container tightly sealed when not in use. Recommended storage temperature: 2-8°C (under refrigeration) for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.