Description

6-(Trifluoromethoxy)-1H-Indole-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a versatile indole scaffold substituted with a trifluoromethoxy group. This compound is valued for its role in the synthesis of novel bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily sought by research institutions and pharmaceutical companies developing new therapeutic agents, especially in areas requiring fluorinated building blocks to modulate pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce the trifluoromethoxy moiety, which can enhance metabolic stability and membrane permeability.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation pesticides and herbicides.
• Fluorinated Compound Library Synthesis: An essential reagent for creating diverse screening libraries focused on fluorinated heterocycles.
• Chemical Biology Probes: Used to develop molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and process development projects.

Basic Information

Product Name	6-(Trifluoromethoxy)-1H-Indole-3-Carboxylic Acid
CAS No.	959238-96-1
Molecular Formula	C10H6F3NO3
Molecular Weight	245.16 g/mol
Synonyms	6-(Trifluoromethoxy)-1H-indole-3-carboxylic acid; 6-(Trifluoromethoxy)indole-3-carboxylic acid; 1H-Indole-3-carboxylic acid, 6-(trifluoromethoxy)-; 959238-96-1; 6-Trifluoromethoxyindole-3-carboxylic acid; 3-Carboxy-6-(trifluoromethoxy)indole; 6-(Trifluoromethoxy)indole-3-carboxylate
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethoxy)-1H-Indole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.