Description

1-Cbz-4-Methyl-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for constructing complex molecular architectures, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptide Synthesis: Used as a protected amino acid component in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the 4-methylpyrrolidine-3-carboxylic acid moiety.
• Chemical Biology Research: Employed in the design and synthesis of peptide mimetics, enzyme inhibitors, and molecular probes for studying biological pathways.
• Asymmetric Synthesis: Acts as a precursor for catalysts or ligands used in enantioselective transformations due to its defined stereogenic centers.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	1-Cbz-4-Methyl-Pyrrolidine-3-Carboxylic Acid
CAS No.	959236-78-3
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-methylpyrrolidine-3-carboxylic Acid; 1-Carbobenzoxy-4-methylpyrrolidine-3-carboxylic Acid; 1-Cbz-4-Methyl-3-pyrrolidinecarboxylic Acid; 4-Methyl-1-[(phenylmethoxy)carbonyl]-3-pyrrolidinecarboxylic Acid; N-Cbz-4-Methyl-DL-proline-3-carboxylic Acid; (RS)-1-[(Benzyloxy)carbonyl]-4-methylpyrrolidine-3-carboxylic Acid; Z-4-Methylpyrrolidine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-Cbz-4-Methyl-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.