Description

4-(Trifluoromethyl)-1H-Indazole-3-Carboxylic Acid is a high-value fluorinated indazole derivative serving as a critical building block in modern organic synthesis. Its core value lies in the trifluoromethyl group, which is strategically incorporated to enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and anti-cancer agent research.
• Agrochemical Synthesis: Used in the design and synthesis of advanced herbicides and pesticides, leveraging the fluorine moiety for improved efficacy and environmental profile.
• Material Science Research: Acts as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Employed in the creation of labeled compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and scale-up activities.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Indazole-3-Carboxylic Acid
CAS No.	959236-61-4
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.14 g/mol
Synonyms	4-(Trifluoromethyl)-1H-indazole-3-carboxylic acid; 1H-Indazole-3-carboxylic acid, 4-(trifluoromethyl)-; 959236-61-4; 4-Trifluoromethyl-1H-indazole-3-carboxylic acid; 3-Carboxy-4-trifluoromethylindazole
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethyl)-1H-Indazole-3-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for research and commercial-scale supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.