Description

4-(Trifluoromethoxy)Isatin is a specialized fluorinated derivative of the isatin heterocycle, serving as a high-value synthetic intermediate. This compound is prized for its trifluoromethoxy substituent, which imparts unique electronic and steric properties critical for modulating the biological activity and physicochemical profile of target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Research: Used in developing novel pesticides and herbicides, where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probe Development: Employed in the design and synthesis of enzyme inhibitors and molecular probes for biochemical pathway analysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring fluorinated isatin scaffolds.

Basic Information

Product Name	4-(Trifluoromethoxy)Isatin
CAS No.	959236-54-5
Molecular Formula	C9H4F3NO3
Molecular Weight	231.13 g/mol
Synonyms	4-(Trifluoromethoxy)-1H-indole-2,3-dione; 1H-Indole-2,3-dione, 4-(trifluoromethoxy)-; Isatin, 4-(trifluoromethoxy)-; 4-Trifluoromethoxyisatin; 4-TFMOI; 959236-54-5
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Isatin is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect this light-sensitive compound from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.