Description

5-Trifluoromethoxy-3-(4-Piperidinyl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic indole core substituted with a trifluoromethoxy group and a piperidinyl moiety. This compound is of significant value for medicinal chemistry research and development, offering a versatile scaffold for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Protease Inhibitor Development: Serves as a precursor or intermediate in the development of enzyme inhibitors due to its specific structural features.
• Ligand Synthesis for Receptor Studies: Employed in the creation of ligands for pharmacological characterization of various G-protein coupled receptors (GPCRs).
• Chemical Biology Probes: Utilized in the development of chemical probes to study biological pathways and protein functions.
• Academic & Institutional R&D: Sourced by universities and research institutes for fundamental organic synthesis and pharmacological research projects.

Basic Information

Product Name	5-Trifluoromethoxy-3-(4-Piperidinyl)-1H-Indole
CAS No.	959236-40-9
Molecular Formula	C15H17F3N2O
Molecular Weight	298.31 g/mol
Synonyms	5-(Trifluoromethoxy)-3-(4-piperidinyl)-1H-indole; 3-(Piperidin-4-yl)-5-(trifluoromethoxy)-1H-indole; 1H-Indole, 5-(trifluoromethoxy)-3-(4-piperidinyl)-; 959236-40-9; 5-Trifluoromethoxy-3-piperidin-4-yl-1H-indole; 3-(4-Piperidyl)-5-trifluoromethoxyindole
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethoxy-3-(4-Piperidinyl)-1H-Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for advanced intermediates, ensuring traceability and documentation suitable for pre-clinical and early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.