Description

4-(Trifluoromethyl)-1H-Indole-3-Carbaldehyde is a high-value fluorinated indole derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, enhancing their biological activity and physicochemical profile. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for improved efficacy and environmental stability.
• Material Science Precursor: Employed in the creation of specialized organic electronic materials and liquid crystals due to its electron-withdrawing character and rigid indole structure.
• Fluorine Chemistry Research: Serves as a model substrate for studying fluorination reactions and the effects of the CF3 group on heterocyclic systems.
• Bioconjugation & Probe Development: The aldehyde functionality allows for facile conjugation to biomolecules, making it useful for creating fluorescent probes or affinity tags.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Indole-3-Carbaldehyde
CAS No.	959236-12-5
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	4-(Trifluoromethyl)-1H-indole-3-carboxaldehyde; 3-Formyl-4-(trifluoromethyl)indole; 4-Trifluoromethylindole-3-carbaldehyde; 1H-Indole-3-carboxaldehyde, 4-(trifluoromethyl)-; 959236-12-5; 4-CF3-indole-3-carbaldehyde
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1H-Indole-3-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for advanced research and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.