Description

7-(Trifluoromethyl)Indoline is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring an indoline scaffold substituted with a highly electron-withdrawing trifluoromethyl group, makes it a critical intermediate for developing novel compounds with enhanced properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to create new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF₃ group can improve biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Fluorine Chemistry Research: An important compound for academic and industrial research exploring the effects of fluorine substitution on reactivity and molecular properties.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	7-(Trifluoromethyl)Indoline
CAS No.	959236-00-1
Molecular Formula	C₉H₈F₃N
Molecular Weight	187.16 g/mol
Synonyms	7-(Trifluoromethyl)-2,3-dihydro-1H-indole; 1H-Indole, 2,3-dihydro-7-(trifluoromethyl)-; 7-Trifluoromethylindoline; 2,3-Dihydro-7-(trifluoromethyl)-1H-indole; Indoline, 7-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)Indoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.