Description

Erythromycin D3 CAS NO 959119-26-7 is a deuterium-labeled analog of the macrolide antibiotic erythromycin, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is a critical tool for quantitative bioanalytical research, providing unmatched accuracy in mass spectrometry-based pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a precise and reliable internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of erythromycin and its metabolites in biological matrices.
• Pharmacokinetic (PK) Studies: Enables accurate determination of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Used as a tracer to elucidate metabolic pathways and identify unknown metabolites with high specificity.
• Bioanalytical Method Development & Validation: Essential for developing, optimizing, and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Drug-Drug Interaction Studies: Facilitates research into how erythromycin interacts with other drugs by providing a stable isotopic reference for precise measurement.
• Environmental & Food Safety Testing: Applied in residue analysis for monitoring erythromycin levels in environmental samples and food products.

Basic Information

Product Name	Erythromycin D3
CAS No.	959119-26-7
Molecular Formula	C37H64D3NO13
Molecular Weight	~737.94 g/mol
Synonyms	Erythromycin (D3); Erythromycin-d3; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione (D3); Deuterated Erythromycin; Erythromycin Internal Standard; Stable Isotope-Labeled Erythromycin
EINECS	Contact for details

Quality Control

Our Erythromycin D3 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR and high-resolution mass spectrometry to confirm the deuteration pattern and position. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for isotopic purity, chemical purity, and residual solvents, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Isotopic Purity (by MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.