Description

5-Oxazolecarboxylic Acid, 4-Methyl-, Trimethylsilyl Ester is a high-purity organosilicon-protected derivative of a substituted oxazole carboxylic acid. This compound serves as a critical advanced synthetic intermediate and building block in complex organic synthesis, particularly for pharmaceuticals and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing heterocyclic scaffolds and protecting reactive carboxyl groups during multi-step syntheses.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing oxazole or related heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific heterocyclic motifs.
• Material Science Research: Serves as a precursor for organic electronic materials, ligands for catalysts, and other functional molecules where a protected carboxylic acid group is required.
• Academic & Industrial R&D: Employed in method development and exploratory chemistry for creating new chemical entities and libraries for screening.
• Peptide Mimetics & Bio-conjugates: The trimethylsilyl ester group allows for selective deprotection, making it useful in the synthesis of peptide analogs and bioconjugation linkers.

Basic Information

Product Name	5-Oxazolecarboxylic Acid, 4-Methyl-, Trimethylsilyl Ester
CAS No.	959070-80-5
Molecular Formula	C8H13NO3Si
Molecular Weight	199.28 g/mol
Synonyms	4-Methyl-1,3-oxazole-5-carboxylic acid trimethylsilyl ester; Trimethylsilyl 4-methyl-1,3-oxazole-5-carboxylate; 4-Methyloxazole-5-carboxylic Acid TMS Ester; 4-Methyl-5-oxazolecarboxylic Acid Trimethylsilyl Ester; 4-Methyl-oxazole-5-carboxylic acid trimethylsilyl ester; TMS ester of 4-methyl-5-oxazolecarboxylic acid; 959070-80-5
EINECS	Contact for details

Quality Control

Our 5-Oxazolecarboxylic Acid, 4-Methyl-, Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation by NMR and IR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.