Description

4,5-Diiodo-1-trityl-1H-imidazole is a highly functionalized imidazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic placement of iodine atoms and the trityl protecting group, which enable precise, site-specific coupling reactions and deprotection sequences. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel nucleoside analogs, antiviral agents, and complex heterocyclic scaffolds for drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Agrochemical Research: Used in the development of new fungicides and herbicides that target specific biological pathways.
• Material Science: Serves as a precursor for creating functionalized polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The iodine atoms make it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to form complex biaryl structures.
• Protecting Group Chemistry: The trityl group allows for selective protection of the imidazole nitrogen, facilitating multi-step synthetic routes.
• Chemical Biology & Probe Development: Used to create labeled compounds or molecular probes for studying enzyme mechanisms and biomolecular interactions.

Basic Information

Product Name	4,5-Diiodo-1-trityl-1H-imidazole
CAS No.	959034-55-0
Molecular Formula	C22H16I2N2
Molecular Weight	602.18 g/mol
Synonyms	1-Trityl-4,5-diiodoimidazole; 4,5-Diiodo-1-(triphenylmethyl)-1H-imidazole; 1H-Imidazole, 4,5-diiodo-1-(triphenylmethyl)-; 4,5-Diiodo-1-tritylimidazole; 959034-55-0; 4,5-Diiodo-1-trityl-imidazole; 1-(Triphenylmethyl)-4,5-diiodo-1H-imidazole
EINECS	Contact for details

Quality Control

Our production of 4,5-Diiodo-1-trityl-1H-imidazole adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to light and oxidation, prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.