Description

8-Azabicyclo[3.2.1]Octan-2-One Hydrochloride is a high-purity pharmaceutical intermediate and building block with the CAS number 958812-40-3. This compound is valued for its rigid, bridged bicyclic structure, which serves as a critical scaffold in modern medicinal chemistry for developing novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of complex molecules targeting central nervous system (CNS) disorders, pain management, and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new active pharmaceutical ingredients (APIs), particularly for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Alkaloid Synthesis: Serves as a building block for the synthesis of complex natural product analogs and tropane alkaloid derivatives.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and receptor interactions.
• Process Chemistry & Scale-Up: Utilized in route development and optimization for the commercial-scale manufacturing of target molecules.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Octan-2-One Hydrochloride
CAS No.	958812-40-3
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	2-Oxo-8-azabicyclo[3.2.1]octane hydrochloride; 8-Azabicyclo[3.2.1]octan-2-one, hydrochloride; Tropinone hydrochloride; 3-Oxotropane hydrochloride; 8-Azabicyclo[3.2.1]octan-2-one HCl; Nortropinone hydrochloride; 8-Methyl-8-azabicyclo[3.2.1]octan-3-one hydrochloride (common misnomer); 8-Azabicyclo[3.2.1]octan-2-one monohydrochloride
EINECS	Contact for details

Quality Control

Our 8-Azabicyclo[3.2.1]Octan-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.