Description

2-Methyl-4-Trifluoromethyl-Thiazol-5-Ylamine is a high-value, fluorinated thiazole derivative serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl-thiazole scaffold, which is essential for developing compounds with enhanced metabolic stability and bioavailability. This intermediate is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and production of novel drug candidates, particularly in therapeutic areas requiring fluorinated heterocycles.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Employed in the synthesis of specialty chemicals, ligands, and advanced materials that benefit from fluorine incorporation.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for creating molecular probes and enzyme inhibitors used in biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Methyl-4-Trifluoromethyl-Thiazol-5-Ylamine
CAS No.	958452-22-7
Molecular Formula	C5H5F3N2S
Molecular Weight	182.17 g/mol
Synonyms	5-Amino-2-methyl-4-(trifluoromethyl)thiazole; 4-(Trifluoromethyl)-2-methyl-5-thiazolamine; 2-Methyl-4-(trifluoromethyl)-1,3-thiazol-5-amine; 2-Methyl-4-trifluoromethylthiazol-5-amine; 5-Amino-2-methyl-4-trifluoromethylthiazole; 2-Methyl-4-trifluoromethyl-5-aminothiazole; 5-Amino-2-methyl-4-(trifluoromethyl)-1,3-thiazole
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-4-Trifluoromethyl-Thiazol-5-Ylamine undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials such as strong alkalis and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.