Description

4-Difluoromethoxy-3-Trifluoromethyl-Benzeneboronic Acid is a high-value organoboron building block, specifically a benzeneboronic acid derivative, critical for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce a difluoromethoxy-trifluoromethylphenyl moiety to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced herbicide and pesticide molecules, where the difluoromethoxy and trifluoromethyl groups can improve metabolic stability, lipophilicity, and biological activity.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials that require specific fluorinated aromatic structures.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura couplings to form biaryl and heterobiaryl bonds, a fundamental transformation in medicinal and process chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	4-Difluoromethoxy-3-Trifluoromethyl-Benzeneboronic Acid
CAS No.	958451-79-1
Molecular Formula	C9H6BF5O3
Molecular Weight	267.95 g/mol
Synonyms	[4-(Difluoromethoxy)-3-(trifluoromethyl)phenyl]boronic acid; 3-Trifluoromethyl-4-difluoromethoxybenzeneboronic acid; 4-(Difluoromethoxy)-3-(trifluoromethyl)benzeneboronic acid; Boronic acid, B-[4-(difluoromethoxy)-3-(trifluoromethyl)phenyl]-; 4-Difluoromethoxy-3-trifluoromethylphenylboronic acid; 958451-79-1 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-Difluoromethoxy-3-Trifluoromethyl-Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.