Description

2-Difluoromethoxy-3-Fluoro-Benzeneboronic Acid is a highly functionalized boronic acid derivative, a crucial building block in modern synthetic chemistry. Its value lies in its unique difluoromethoxy and fluoro substituents, which are strategically placed to modulate the electronic and steric properties of target molecules. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or precursor for creating novel organic electronic materials, such as OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated aromatic architectures.

Basic Information

Product Name	2-Difluoromethoxy-3-Fluoro-Benzeneboronic Acid
CAS No.	958451-76-8
Molecular Formula	C7H6BF3O3
Molecular Weight	201.93 g/mol
Synonyms	(2-(Difluoromethoxy)-3-fluorophenyl)boronic acid; 3-Fluoro-2-(difluoromethoxy)benzeneboronic acid; 2-(Difluoromethoxy)-3-fluorobenzeneboronic acid; Boronic acid, B-[2-(difluoromethoxy)-3-fluorophenyl]-; 958451-76-8; 2-Difluoromethoxy-3-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxy-3-Fluoro-Benzeneboronic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.