Description

Naproxen-D3 is a deuterium-labeled analog of the widely used non-steroidal anti-inflammatory drug (NSAID) naproxen. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of naproxen in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for Bioanalysis: Serves as a critical reference standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methods for quantifying naproxen in plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of naproxen.
• Clinical Research: Enables accurate measurement of drug concentration in patients during clinical trials for bioequivalence and therapeutic drug monitoring.
• Forensic and Anti-Doping Analysis: Supports precise detection and quantification of naproxen in forensic toxicology and sports doping control.
• Pharmaceutical Quality Control: Can be utilized in method development and validation for the assay of naproxen in pharmaceutical formulations.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques that require a labeled isotopologue for optimal accuracy.

Basic Information

Product Name	Naproxen-D3
CAS No.	958293-79-3
Molecular Formula	C₁₄H₁₁D₃O₃
Molecular Weight	233.27 g/mol
Synonyms	(+)-(S)-2-(6-Methoxy-2-naphthyl)propionic-3,3,3-d3 acid; Deuterated Naproxen; Naproxen-methyl-d3; Naproxen-d3 (methyl-d3); 2-(6-Methoxynaphthalen-2-yl)-3,3,3-trideuteriopropanoic acid; (S)-Naproxen-d3; (+)-Naproxen-d3; ALY-5840-d3
EINECS	Contact for details

Quality Control

Our Naproxen-D3 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and MS, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for assay, isotopic enrichment, and related substances. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.