Description

n-Methyl-n-[4-Morpholinyl(3-Oxido-1H-1,2,3-Triazolo[4,5-B]Pyridin-1-Yl)Methylene]Methanaminium, Hexafluorophosphate is a specialized organic salt primarily used as a high-performance coupling reagent in peptide synthesis. Its value lies in its ability to efficiently activate carboxylic acids, minimizing racemization and enabling the formation of complex amide bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable and high-purity reagents for the development of peptide-based therapeutics and other advanced organic molecules.

Application

• Peptide Synthesis: As a key coupling reagent for solid-phase and solution-phase peptide synthesis, facilitating the formation of amide bonds between amino acids.
• Pharmaceutical Research & Development: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide drugs and complex organic molecules.
• Bioconjugation: Employed in linking biomolecules, such as proteins or antibodies, to other molecules for diagnostic or therapeutic applications.
• Organic Synthesis: Acts as a versatile reagent for amide bond formation in the synthesis of various heterocyclic compounds and natural product analogs.
• Combinatorial Chemistry: Utilized in high-throughput screening libraries for drug discovery due to its efficiency and reliability.
• Material Science: Potential use in the synthesis of specialized polymers and advanced materials requiring precise molecular assembly.

Basic Information

Product Name	n-Methyl-n-[4-Morpholinyl(3-Oxido-1H-1,2,3-Triazolo[4,5-B]Pyridin-1-Yl)Methylene]Methanaminium, Hexafluorophosphate
CAS No.	958029-37-3
Molecular Formula	C13H17F6N6O2P
Molecular Weight	434.29 g/mol
Synonyms	HATU Hexafluorophosphate; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (common misnomer); O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (incorrect but used); Hexafluorophosphate Salt of HATU; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; Uranium HATU Salt; Coupling Reagent 958029-37-3.
EINECS	Contact for details

Quality Control

Our n-Methyl-n-[4-Morpholinyl(3-Oxido-1H-1,2,3-Triazolo[4,5-B]Pyridin-1-Yl)Methylene]Methanaminium, Hexafluorophosphate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry atmosphere to prevent decomposition. For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.