Description

trans-3-Aminocyclobutanecarboxylic Acid Ethyl Ester Hydrochloride is a high-purity, pharmaceutically relevant building block, specifically the hydrochloride salt of a constrained β-amino acid derivative. This compound is a critical chiral intermediate for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecules with cyclobutane scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate rigid, conformationally restricted cyclobutane rings into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Academic & Industrial R&D: Essential for exploratory chemistry in academic institutions and corporate R&D laboratories focused on novel chemical space.
• Custom Synthesis & Scale-Up: A starting material for contract research and manufacturing organizations (CROs/CMOs) offering custom synthesis services from milligram to kilogram scale.

Basic Information

Product Name	trans-3-Aminocyclobutanecarboxylic Acid Ethyl Ester Hydrochloride
CAS No.	957793-36-1
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	trans-3-Aminocyclobutanecarboxylic acid ethyl ester hydrochloride; Ethyl trans-3-aminocyclobutanecarboxylate hydrochloride; (1r,3r)-3-Aminocyclobutanecarboxylic Acid Ethyl Ester Hydrochloride; (1s,3s)-3-Aminocyclobutanecarboxylic Acid Ethyl Ester Hydrochloride; trans-3-Amino-1-cyclobutanecarboxylic Acid Ethyl Ester HCl; Ethyl 3-aminocyclobutanecarboxylate hydrochloride (trans); ACBC Ethyl Ester Hydrochloride; 1,3-trans-3-Aminocyclobutanecarboxylic acid ethyl ester HCl
EINECS	Contact for details

Quality Control

Our trans-3-Aminocyclobutanecarboxylic Acid Ethyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.