Description

9-Fluorenylmethylthiol is a specialized organosulfur compound featuring a fluorenylmethyl protecting group. This chemical is valued for its role as a key intermediate and protecting group reagent in sophisticated organic synthesis, particularly in peptide and pharmaceutical chemistry. It is essential for researchers and manufacturers in the fine chemical, pharmaceutical, and biotechnology sectors who require high-purity building blocks for complex molecule assembly.

Application

• Peptide Synthesis: Used as a thiol-protecting group (Fm-thiol) during solid-phase and solution-phase peptide synthesis to prevent unwanted side reactions.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates containing thiol functionalities.
• Bioconjugation Chemistry: Employed in the site-specific modification of proteins, antibodies, and other biomolecules for drug delivery systems and diagnostic probes.
• Material Science Research: Acts as a precursor or modifying agent in the development of novel polymers and functional materials with tailored properties.
• Chemical Biology Probes: Utilized in the creation of activity-based probes and labeling reagents to study enzymatic activity and biological pathways.
• Asymmetric Synthesis: Functions as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to produce enantiomerically pure compounds.

Basic Information

Item	Details
Product Name	9-Fluorenylmethylthiol
CAS No.	957753-00-3
Molecular Formula	C14H12S
Molecular Weight	212.31 g/mol
Synonyms	Fm-thiol; 9H-Fluoren-9-ylmethanethiol; (9H-Fluoren-9-yl)methanethiol; 9-Fluorenylmethanethiol; N-(9-Fluorenylmethyl)thiol; Fm-SH; 9-Fluorenylmethyl Mercaptan
EINECS	Contact for details

Quality Control

Our 9-Fluorenylmethylthiol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.