Description

p-Toluenethiol CAS NO 106-45-6 is a versatile aromatic thiol compound, also known as 4-methylbenzenethiol. This organosulfur chemical is valued for its strong nucleophilic and reducing properties, making it a critical intermediate in advanced organic synthesis. It is essential for manufacturers in the agrochemical, pharmaceutical, and polymer industries seeking to introduce thiol or sulfide functional groups into complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing sulfur-based functional groups.
• Agrochemical Synthesis: Used in the production of pesticides, herbicides, and fungicides where the thiol group acts as a reactive site.
• Polymer Modification & Cross-linking Agent: Serves as a chain transfer agent in radical polymerizations and a cross-linker for specialty rubbers and resins.
• Organic Synthesis Reagent: Employed as a nucleophile in substitution reactions and for the preparation of sulfides, disulfides, and other sulfur-containing compounds.
• Flavor & Fragrance Industry: Acts as a precursor for certain sulfur-containing aroma chemicals, contributing to savory or meaty notes.
• Chemical Research & Development: Utilized in laboratories for method development and the synthesis of novel chemical entities.

Basic Information

Product Name	p-Toluenethiol
CAS No.	106-45-6
Molecular Formula	C7H8S
Molecular Weight	124.20 g/mol
Synonyms	4-Methylbenzenethiol; 4-Mercaptotoluene; p-Thiocresol; 4-Toluenethiol; p-Methylphenyl mercaptan; 4-Methylphenylthiol; Tolyl mercaptan; 1-Methyl-4-mercaptobenzene
EINECS	203-397-0

Quality Control

Our p-Toluenethiol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat, sparks, and open flame. Due to its highly volatile and light-sensitive nature, the product should be kept under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent oxidation. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total
Specific Gravity (20°C)	1.00 - 1.02
Refractive Index (20°C)	1.575 - 1.585

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.