Description

Boc-(R)-α-(4-Trifluoromethyl-Benzyl)-Proline is a high-purity, non-natural amino acid derivative featuring a Boc-protected proline core and a chiral benzyl side chain substituted with a trifluoromethyl group. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering enhanced metabolic stability and lipophilicity to peptide-based drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and GPCR-targeted ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and central nervous system (CNS) diseases.
• Peptidomimetic Drug Design: Used to introduce constrained proline analogs and fluorinated aromatic motifs into peptide backbones to improve bioavailability and binding affinity.
• Protease Inhibitor Synthesis: Serves as a core structural component in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology & Probe Development: Employed in the synthesis of labeled compounds or activity-based probes for studying enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective organic transformations to construct complex molecular architectures.
• Agrochemical Research: Potential intermediate in the discovery of novel herbicides or fungicides with optimized properties.

Basic Information

Product Name	Boc-(R)-α-(4-Trifluoromethyl-Benzyl)-Proline
CAS No.	957310-45-1
Molecular Formula	C₁₈H₂₂F₃NO₄
Molecular Weight	373.37 g/mol
Synonyms	1-Boc-3-[(R)-α-(4-Trifluoromethylbenzyl)]proline; tert-Butyl (2R)-2-[(4-Trifluoromethylphenyl)methyl]pyrrolidine-1-carboxylate; (R)-1-(tert-Butoxycarbonyl)-2-(4-trifluoromethylbenzyl)pyrrolidine-2-carboxylic Acid; Boc-(R)-3-(4-Trifluoromethylbenzyl)proline; N-Boc-(R)-α-(4-CF₃-Bn)-Pro-OH; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-2-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxylic Acid; Boc-(R)-Tfm-Bn-Pro-OH
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-(4-Trifluoromethyl-Benzyl)-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.