Description

1-Piperazineethanesulfonamide, 4-Methyl-n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is a high-value, advanced pharmaceutical intermediate featuring a piperazine core and a pinacol boronate ester functional group. This compound matters for its critical role as a key building block in modern medicinal chemistry, specifically in the synthesis of targeted small-molecule therapeutics. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other bioactive molecules, particularly for oncology and inflammatory disease applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronate ester group makes it an essential reagent for constructing biaryl and heterobiaryl structures central to many active pharmaceutical ingredients (APIs).
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Bioconjugation & Probe Development: Serves as a versatile handle for creating labeled compounds for biochemical assays and diagnostic research.
• Chemical Biology Research: Employed in the development of molecular probes to study enzyme function and cellular signaling pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	1-Piperazineethanesulfonamide, 4-Methyl-n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-
CAS No.	957198-23-1
Molecular Formula	C19H32BN3O4S
Molecular Weight	409.35 g/mol
Synonyms	4-Methyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-piperazineethanesulfonamide; 1-Piperazineethanesulfonamide, 4-methyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-Methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-ethanesulfonamide; 957198-23-1; BRN 19115345; 4-Methyl-N-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-piperazineethanesulfonamide
EINECS	Contact for details

Quality Control

Our 1-Piperazineethanesulfonamide derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural integrity suitable for sensitive pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.