Description

3-Chloro-5-(Methylcarbamoyl)Phenylboronic Acid is a high-purity, functionalized phenylboronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a chloro and an amide substituent for further derivatization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in constructing complex molecules for crop protection agents and herbicides.
• Material Science: Building block for creating functionalized polymers, organic electronic materials, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Utilized in the development of chemical probes, sensors, and affinity ligands targeting biomolecules.
• Cross-Coupling Reactions: Serves as a versatile boronic acid partner in palladium-catalyzed Suzuki-Miyaura cross-couplings to form biaryl linkages.
• Library Synthesis: Enables rapid generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	3-Chloro-5-(Methylcarbamoyl)Phenylboronic Acid
CAS No.	957120-51-3
Molecular Formula	C8H9BClNO3
Molecular Weight	213.42 g/mol
Synonyms	(3-Chloro-5-((methylamino)carbonyl)phenyl)boronic acid; 3-Chloro-5-(N-methylcarbamoyl)benzeneboronic acid; 3-Chloro-5-(methylaminocarbonyl)phenylboronic acid; 5-Borono-3-chloro-N-methylbenzamide; B-[3-Chloro-5-[(methylamino)carbonyl]phenyl]boronic acid; 957120-51-3; 3-Chloro-5-carbamoylphenylboronic Acid Methyl Amide
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Methylcarbamoyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the high standards required for research and process chemistry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.