Description

1-Boc-4-Bromo-2-Indoleboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is critically important for its role in facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex indole-based molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for the discovery and synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to attach diverse aryl and heteroaryl groups to the indole scaffold.
• Agrochemical Research: Used in the development of new active ingredients for crop protection and pest management.
• Material Science: Serves as a precursor for creating organic electronic materials and functional polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the construction of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: Essential reagent for methodological development and library synthesis in academic and CRO laboratories.

Basic Information

Product Name	1-Boc-4-Bromo-2-Indoleboronic Acid
CAS No.	957034-29-6
Molecular Formula	C₁₃H₁₅BBrNO₄
Molecular Weight	340.98 g/mol
Synonyms	1-Boc-4-Bromo-1H-indole-2-boronic Acid; 4-Bromo-1-[(tert-butoxy)carbonyl]-1H-indole-2-boronic Acid; tert-Butyl 4-bromo-2-borono-1H-indole-1-carboxylate; 1-Boc-4-Bromoindole-2-boronic Acid; 4-Bromo-1-Boc-indole-2-boronic Acid; 1-(tert-Butoxycarbonyl)-4-bromo-1H-indole-2-boronic Acid; 957034-29-6; BRN 15424863
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Bromo-2-Indoleboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its sensitivity to moisture and oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area Percent)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.