Description

1H-Indole, 6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a valuable indole core functionalized with both a fluorine atom and a pinacol boronate ester group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex carbon-carbon bonds. It is an essential building block for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries, enabling the efficient synthesis of novel, fluorinated bioactive molecules and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-infective research, leveraging the Suzuki coupling for rapid scaffold diversification.
• Agrochemical Research: Used to create new active ingredients for crop protection agents, where the fluorine atom and indole moiety can enhance biological activity and environmental stability.
• Material Science & OLED Development: Serves as a key monomer or building block for constructing organic semiconductors, light-emitting diodes (OLEDs), and other advanced electronic materials.
• Chemical Biology & Probe Synthesis: Employed in the development of fluorescent probes, enzyme inhibitors, and other tools for biological target identification and validation.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in university and CRO (Contract Research Organization) laboratories.
• Library Synthesis for High-Throughput Screening: Enables the parallel synthesis of diverse compound libraries to accelerate hit discovery in drug development pipelines.

Basic Information

Item	Details
Product Name	1H-Indole, 6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	955978-85-5
Molecular Formula	C₁₆H₂₁BFNO₂
Molecular Weight	289.16 g/mol
Synonyms	6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoro-1H-indole; 6-Fluoro-1H-indole-4-boronic acid pinacol ester; 6-Fluoro-4-indolylboronic acid pinacol ester; 6-Fluoro-4-boronindole pinacol ester; (6-Fluoro-1H-indol-4-yl)boronic acid pinacol ester; PINACOL 6-FLUORO-1H-INDOLE-4-BORONATE; CAS 955978-85-5
EINECS	Contact for details

Quality Control

Our production of 1H-Indole, 6-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation, especially after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.