Description

4-Bromo-2-(Trifluoromethyl)-1H-Indole is a versatile and highly functionalized indole derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both bromine and trifluoromethyl substituents, makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the bioactivity of the indole core and halogenated motifs.
• Material Science: Serves as a monomer or functional unit in the creation of specialty polymers and organic electronic materials.
• Chemical Synthesis: Acts as a versatile scaffold for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce complex aromatic systems.
• Fluorine Chemistry: The trifluoromethyl group provides a source of fluorine for designing compounds with enhanced metabolic stability and lipophilicity.
• Academic & Contract Research: Essential reagent for methodological development and exploring new reaction pathways in heterocyclic chemistry.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)-1H-Indole
CAS No.	955978-75-3
Molecular Formula	C9H5BrF3N
Molecular Weight	264.04 g/mol
Synonyms	4-Bromo-2-(trifluoromethyl)-1H-indole; 1H-Indole, 4-bromo-2-(trifluoromethyl)-; 4-Bromo-2-trifluoromethylindole; 2-Trifluoromethyl-4-bromoindole; 4-Bromo-2-(trifluoromethyl)indole; 955978-75-3; 4-Br-2-CF3-1H-Indole
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-(Trifluoromethyl)-1H-Indole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.