Description

4-(Chloromethyl)-2-[3-Methyl-5-(Trifluoromethyl)-1H-Pyrazol-1-Yl]-1,3-Thiazole is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active ingredients. This compound is valued for its unique heterocyclic structure, which incorporates a reactive chloromethyl group and a trifluoromethyl-substituted pyrazole moiety, making it a versatile building block in modern medicinal chemistry. It is primarily utilized by research and development teams and production chemists in the pharmaceutical and agrochemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral medications.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation pesticides and herbicides, leveraging the bioactivity of the thiazole and pyrazole rings.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new chemical entities and structure-activity relationships (SAR) in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the scale-up and production of proprietary molecules under cGMP conditions.
• Fluorinated Compound Libraries: An essential component for creating focused libraries of fluorinated compounds, which are highly sought after for their metabolic stability and membrane permeability in drug discovery.

Basic Information

Product Name	4-(Chloromethyl)-2-[3-Methyl-5-(Trifluoromethyl)-1H-Pyrazol-1-Yl]-1,3-Thiazole
CAS No.	955976-93-9
Molecular Formula	C9H7ClF3N3S
Molecular Weight	281.68 g/mol
Synonyms	4-(Chloromethyl)-2-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazole; 1,3-Thiazole, 4-(chloromethyl)-2-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-; 2-(3-Methyl-5-trifluoromethyl-1H-pyrazol-1-yl)-4-chloromethylthiazole; 4-Chloromethyl-2-(3-methyl-5-trifluoromethylpyrazol-1-yl)thiazole; 955976-93-9; 4-(Chloromethyl)-2-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1,3-thiazole
EINECS	Contact for details

Quality Control

Every batch of 4-(Chloromethyl)-2-[3-Methyl-5-(Trifluoromethyl)-1H-Pyrazol-1-Yl]-1,3-Thiazole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. We adhere to relevant guidelines and can support development under cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.