Description

(8β)-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-6-Methylergoline CAS NO 955957-39-8 is a key, high-purity synthetic intermediate in advanced pharmaceutical research and development. This compound is specifically designed for the synthesis of complex ergoline alkaloid derivatives, offering a protected functional group for precise downstream chemical transformations. It is an essential building block for medicinal chemists and process development scientists working in central nervous system (CNS) drug discovery, particularly for targeting serotonin and dopamine receptor pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel ergot alkaloid-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the development of investigational compounds for the treatment of neurological disorders such as Parkinson's disease and migraines.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry: Employed in route scouting and scale-up optimization for the commercial manufacturing of complex therapeutic molecules.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.
• Contract Research & Manufacturing (CRAM): A valuable material for organizations specializing in custom synthesis and development services for the biopharma industry.

Basic Information

Product Name	(8β)-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-6-Methylergoline
CAS No.	955957-39-8
Molecular Formula	C22H36N2O2Si
Molecular Weight	388.63 g/mol
Synonyms	6-Methyl-8β-[[(tert-butyldimethylsilyl)oxy]methyl]ergoline; 8β-[[(tert-Butyldimethylsilyl)oxy]methyl]-6-methylergoline; TBDMS-protected 8-hydroxymethyl-6-methylergoline; 6-Methylergoline-8β-methanol, TBDMS ether; tert-Butyldimethylsilyl 8β-(hydroxymethyl)-6-methylergoline ether; (8β)-8-(((tert-Butyldimethylsilyl)oxy)methyl)-6-methylergoline
EINECS	Contact for details

Quality Control

Our (8β)-8-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-6-Methylergoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.