Description

(3R)-3-((3,5-Dichloro-4-Fluoro-[1,1-Biphenyl]-4-Yl)Methyl)-1-(4,5,6,7-Tetrahydro-2H-Indazol-6-Yl)Pyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, particularly for its potential role as a key building block in novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the life sciences sector. Its precise stereochemistry and functional groups make it a critical component for synthesizing targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its complex, functionalized molecular scaffold.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients (APIs), especially those targeting specific biological pathways.
• Preclinical Studies: Utilized to produce compounds for in vitro and in vivo biological testing and pharmacological profiling.
• Fine Chemical Synthesis: Acts as a specialized reagent for constructing complex organic molecules in advanced synthetic chemistry.
• Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis projects and scale-up activities under cGMP or research-grade conditions.

Basic Information

Product Name	(3R)-3-((3,5-Dichloro-4-Fluoro-[1,1-Biphenyl]-4-Yl)Methyl)-1-(4,5,6,7-Tetrahydro-2H-Indazol-6-Yl)Pyrrolidin-2-One
CAS No.	955407-70-2
Molecular Formula	C25H24Cl2FN3O
Molecular Weight	472.38 g/mol
Synonyms	1-(4,5,6,7-Tetrahydro-2H-indazol-6-yl)-3-[(3,5-dichloro-4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-2-pyrrolidinone, (3R)-; PF-06409577 (Potential research code); Biphenyl-indazolyl pyrrolidinone derivative; (R)-enantiomer of a biphenyl-pyrrolidinone intermediate; 6-[3-[(3,5-Dichloro-4'-fluoro[1,1'-biphenyl]-4-yl)methyl]-2-oxo-1-pyrrolidinyl]-4,5,6,7-tetrahydro-2H-indazole; CAS 955407-70-2
EINECS	Contact for details

Quality Control

Our (3R)-3-((3,5-Dichloro-4-Fluoro-[1,1-Biphenyl]-4-Yl)Methyl)-1-(4,5,6,7-Tetrahydro-2H-Indazol-6-Yl)Pyrrolidin-2-One is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure high chemical and isomeric purity suitable for demanding research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles as determined by HPLC, NMR, and MS. We support development with custom synthesis and rigorous quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.