Description

4,4-Dihydroxy-4,5,6,7-Tetrahydro-Indazole-1-Carboxylic Acid tert-Butyl Ester Hydrate is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• API Synthesis: Serves as a crucial precursor in multi-step synthetic routes for the production of complex Active Pharmaceutical Ingredients.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.

Basic Information

Product Name	4,4-Dihydroxy-4,5,6,7-Tetrahydro-Indazole-1-Carboxylic Acid tert-Butyl Ester Hydrate
CAS No.	955406-75-4
Molecular Formula	C₁₂H₁₈N₂O₅
Molecular Weight	270.28 g/mol
Synonyms	1H-Indazole-1-carboxylic acid, 4,5,6,7-tetrahydro-4,4-dihydroxy-, 1,1-dimethylethyl ester, hydrate (1:1); 4,4-Dihydroxy-4,5,6,7-tetrahydro-1H-indazole-1-carboxylic acid tert-butyl ester hydrate; tert-Butyl 4,4-dihydroxy-4,5,6,7-tetrahydro-1H-indazole-1-carboxylate hydrate; 4,4-Dihydroxy-4,5,6,7-tetrahydroindazole-1-carboxylic acid tert-butyl ester monohydrate; BOC-protected tetrahydroindazole diol hydrate.
EINECS	Contact for details

Quality Control

Our 4,4-Dihydroxy-4,5,6,7-Tetrahydro-Indazole-1-Carboxylic Acid tert-Butyl Ester Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.