Description

5,6-Difluoroindoline is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters as a key precursor in the development of novel pharmaceuticals and agrochemicals, where its difluoroindoline core imparts unique electronic and metabolic properties to target molecules. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating complex, biologically active compounds.

Application

• Pharmaceutical Intermediate: A critical scaffold in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the fluorine atoms to enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as dyes, pigments, and components for organic light-emitting diodes (OLEDs).
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable substrate for investigating novel fluorination reactions and studying structure-activity relationships (SAR).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Item	Details
Product Name	5,6-Difluoroindoline
CAS No.	954255-04-0
Molecular Formula	C8H7F2N
Molecular Weight	155.15 g/mol
Synonyms	5,6-Difluoro-2,3-dihydro-1H-indole; 1H-Indole, 5,6-difluoro-2,3-dihydro-; 5,6-Difluoroindoline; 2,3-Dihydro-5,6-difluoro-1H-indole; 5,6-Difluoro-2,3-dihydroindole; Difluoroindoline
EINECS	Contact for details

Quality Control

Our 5,6-Difluoroindoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, GC, NMR, and mass spectrometry results. A Certificate of Analysis (COA) is supplied with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from oxidizing agents. Due to its sensitivity, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.