Description

1-Hydroxymethyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a sophisticated chiral building block and key intermediate in organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D laboratories, agrochemical manufacturers, and advanced material scientists need this high-purity intermediate to enable efficient, stereoselective synthetic routes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular diseases.
• Chiral Building Block: Used in asymmetric synthesis to introduce the tetrahydroisoquinoline scaffold, a privileged structure in medicinal chemistry.
• Agrochemical Research: Serves as a key intermediate in developing new generation pesticides and herbicides with specific stereochemical requirements.
• Catalyst and Ligand Synthesis: Employed in the preparation of specialized chiral catalysts and ligands for enantioselective transformations.
• Academic & Contract Research: Utilized in university and CRO settings for methodological development and exploring new chemical space.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value, complex organic molecules for various industrial applications.

Basic Information

Product Name	1-Hydroxymethyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	954239-58-8
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	tert-Butyl 1-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate; 1H-Isoquinoline-2-carboxylic acid, 3,4-dihydro-1-(hydroxymethyl)-, 1,1-dimethylethyl ester; (R/S)-1-Hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; BOC-Protected 1-Hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; 1-(Hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester; THIQ Chiral Ester Intermediate
EINECS	Contact for details

Quality Control

Our 1-Hydroxymethyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.