Description

1-Boc-6-Iodo-2,3-Dihydro-Indole is a versatile and high-purity protected indole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a Boc-protected nitrogen and a reactive iodo substituent, enabling precise functionalization for complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex indole-based drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to introduce diverse aryl, alkenyl, or alkynyl groups at the 6-position.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that utilize the indole scaffold.
• Material Science Precursor: Employed in the synthesis of organic semiconductors and functional dyes due to the electron-rich indole core and halogen handle.
• Peptidomimetics & PROTACs: The Boc-protected amine is a crucial feature for constructing peptide-like structures and proteolysis-targeting chimeras (PROTACs).
• Academic & R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Boc-6-Iodo-2,3-Dihydro-Indole
CAS No.	954239-34-0
Molecular Formula	C₁₃H₁₆INO₂
Molecular Weight	345.18 g/mol
Synonyms	tert-Butyl 6-iodo-2,3-dihydro-1H-indole-1-carboxylate; 6-Iodo-2,3-dihydro-1H-indole-1-carboxylic acid tert-butyl ester; 1-Boc-6-iodoindoline; N-Boc-6-iodoindoline; 1-(tert-Butoxycarbonyl)-6-iodo-2,3-dihydro-1H-indole; 6-Iodo-N-Boc-indoline; Boc-6-I-indoline
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Iodo-2,3-Dihydro-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting the exact specifications and results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.