Description

1-Boc-4-Iodo-2,3-Dihydro-1H-Indole is a versatile and high-value protected indole derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in the strategic placement of both a Boc-protected amine and an iodine atom, enabling sequential and selective functionalization for complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug candidates.
• Cross-Coupling Reactions: The aryl iodide moiety is a prime substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to introduce complex aryl, alkenyl, or alkynyl groups.
• Peptidomimetic & Scaffold Development: Used in constructing constrained peptide analogs and privileged heterocyclic scaffolds for medicinal chemistry and chemical biology.
• Agrochemical Synthesis: Intermediate in the development of new generation herbicides and fungicides with indole core structures.
• Material Science Research: Precursor for functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and for exploring new reaction pathways.

Basic Information

Product Name	1-Boc-4-Iodo-2,3-Dihydro-1H-Indole
CAS No.	954239-31-7
Molecular Formula	C₁₃H₁₆INO₂
Molecular Weight	345.18 g/mol
Synonyms	1-Boc-4-iodoindoline; tert-Butyl 4-iodo-2,3-dihydro-1H-indole-1-carboxylate; 4-Iodo-1-(tert-butoxycarbonyl)indoline; 1-(tert-Butoxycarbonyl)-4-iodo-2,3-dihydro-1H-indole; N-Boc-4-iodoindoline; 4-Iodo-N-Boc-indoline; 954239-31-7; Boc-4-I-indoline
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Iodo-2,3-Dihydro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.