Description

Danirixin is a selective and potent antagonist of the chemokine receptor CXCR2, which plays a key role in neutrophil-mediated inflammation. This targeted mechanism of action makes it a valuable research compound for investigating inflammatory pathways and potential therapeutic applications. It is primarily utilized by pharmaceutical researchers and development scientists in the fields of immunology, respiratory diseases, and oncology.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) in preclinical studies for inflammatory conditions.
• Mechanistic Studies: For investigating the role of the CXCR2 receptor and neutrophil biology in disease models.
• Respiratory Disease Research: Exploration of potential therapies for chronic obstructive pulmonary disease (COPD), asthma, and other neutrophil-driven lung disorders.
• Oncology Research: Studying the tumor microenvironment, cancer-related inflammation, and potential anti-metastatic effects.
• Biochemical Assay Development: Used as a ligand in high-throughput screening (HTS) and binding assays to discover new CXCR2 modulators.
• Academic Research: A critical tool for universities and research institutes focusing on chemokine signaling and immunopharmacology.

Basic Information

Product Name	Danirixin
CAS No.	954126-98-8
Molecular Formula	C₂₀H₂₃N₅O₃
Molecular Weight	381.43 g/mol
Synonyms	GSK1325756; GSK-1325756; GSK 1325756; 2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide; Danirixin (GSK1325756)
EINECS	Contact for details

Quality Control

Our Danirixin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets high-grade standards for research use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.