Description

5-(Trifluoromethoxy)-1H-Indole is a high-value fluorinated indole derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy-substituted indole scaffold is prized for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced potency and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides, where the trifluoromethoxy group can improve biological activity and environmental persistence.
• Material Science Research: Employed in the synthesis of specialty polymers and organic electronic materials due to its electron-withdrawing properties.
• Chemical Biology Probes: Acts as a core structure for developing fluorescent tags and molecular probes for biochemical assays.
• Catalyst & Ligand Development: Serves as a precursor for novel ligands in transition metal catalysis, enabling new synthetic methodologies.

Basic Information

Product Name	5-(Trifluoromethoxy)-1H-Indole
CAS No.	953906-76-8
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	5-(Trifluoromethoxy)indole; 1H-Indole, 5-(trifluoromethoxy)-; 5-Trifluoromethoxyindole; 5-(Trifluoromethoxy)indole; 953906-76-8; 5-(Trifluoromethoxy)-1H-indole; 5-(Trifluoromethoxy)indole, 95%
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethoxy)-1H-Indole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment ensures material consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.