Description

4-((2-(((1R,2R)-2-Hydroxycyclohexyl)Amino)Benzo[D]Thiazol-6-Yl)Oxy)-n-Methylpicolinamide is a sophisticated chiral organic compound featuring a benzothiazole core linked to a substituted picolinamide via an ether bridge. This complex molecular architecture makes it a valuable intermediate for pharmaceutical research and development, particularly in the synthesis of targeted therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors. The compound's defined stereochemistry and functional groups are critical for probing specific biological pathways and developing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, particularly for targeted therapies.
• Kinase Inhibitor Research: Used in medicinal chemistry programs focused on developing inhibitors for various kinase targets due to its benzothiazole and amide motifs.
• Chemical Biology Probe: Acts as a tool compound for studying enzyme function and signal transduction pathways in academic and industrial research settings.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for potential active pharmaceutical ingredients (APIs).
• High-Purity Reference Standard: Supplied as a certified reference material for analytical method development and quality control in pharmaceutical manufacturing.
• Custom Synthesis Starting Material: Provides a versatile scaffold for further chemical modification and library synthesis in drug discovery.

Basic Information

Product Name	4-((2-(((1R,2R)-2-Hydroxycyclohexyl)Amino)Benzo[D]Thiazol-6-Yl)Oxy)-n-Methylpicolinamide
CAS No.	953769-46-5
Molecular Formula	C20H22N4O3S
Molecular Weight	398.48 g/mol
Synonyms	4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methylpyridine-2-carboxamide; N-Methyl-4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)picolinamide; (1R,2R)-N-(6-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)benzo[d]thiazol-2-yl)cyclohexane-1,2-diol; 953769-46-5; Benzothiazole derivative CAS 953769-46-5; Chiral benzothiazole-picolinamide conjugate
EINECS	Contact for details

Quality Control

Our production of 4-((2-(((1R,2R)-2-Hydroxycyclohexyl)Amino)Benzo[D]Thiazol-6-Yl)Oxy)-n-Methylpicolinamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment, supporting compliance with internal quality standards for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.