Description

5-Methyl-1H-Indole-2-Boronic Acid is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those containing the indole scaffold, for therapeutic areas such as oncology and CNS disorders.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products, leveraging its ability to introduce complex substituents.
• Material Science Research: Employed in the creation of organic electronic materials, including organic light-emitting diodes (OLEDs) and conductive polymers, where precise molecular structure is critical.
• Chemical Biology & Probe Development: Utilized as a handle for bioconjugation or in the synthesis of molecular probes for studying biological systems.
• Academic & Contract Research: Serves as a fundamental reagent in university laboratories and CROs (Contract Research Organizations) for methodological development and discovery chemistry.
• Scale-up Process Chemistry: Supplied for process optimization and pilot-scale synthesis under cGMP conditions for advanced clinical trial material production.

Basic Information

Product Name	5-Methyl-1H-Indole-2-Boronic Acid
CAS No.	953411-08-0
Molecular Formula	C9H10BNO2
Molecular Weight	174.99 g/mol
Synonyms	5-Methyl-1H-indole-2-boronic acid; (5-Methyl-1H-indol-2-yl)boronic acid; 5-Methylindole-2-boronic acid; 2-Borono-5-methylindole; 953411-08-0; 5-Methyl-2-indoleboronic acid; Boronic acid, B-(5-methyl-1H-indol-2-yl)-
EINECS	Contact for details

Quality Control

Every batch of our 5-Methyl-1H-Indole-2-Boronic Acid is produced and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible results in sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation, especially after opening the original container. Ideal storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.